Collaborations & Alliances

Merck KGaA, Pfizer Partner with Syndax on Cancer Drug Combo

To evaluate avelumab in combination with Syndax’s entinostat in ovarian cancer

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By: Kristin Brooks

Managing Editor, Contract Pharma

Merck KGaA and Pfizer have entered into a collaboration Syndax Pharmaceuticals to evaluate avelumab, an investigational fully human anti-PD-L1 IgG1 monoclonal antibody, in combination with Syndax’s entinostat, an investigational oral small molecule that targets immune regulatory cells (myeloid-derived suppressor cells and regulatory T-cells), in patients with heavily pre-treated, recurrent ovarian cancer. Avelumab is currently being investigated across a broad range of tumor types under the alli...

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